Independent and combined effects of chronic cannabis use and HIV on insular functional connectivity

Riedel MC, Flannery JS, Laird AR, Gonzalez R, Sutherland MT, HBM (2020).



Cannabis use is prevalent among individuals living with HIV for medicinal purposes, including pain management. The insular cortex plays a critical role in interoceptive function and the sensory-discriminative and affective-motivational aspects of pain. Whereas insular-cortical alterations have been independently linked with CB use and HIV infection in neurocircuits associated with higher-level cognitive functions, the combined impact of CB and HIV in resting-state functional connectivity remains to be clarified. Study purpose: [1] Characterize alterations in insular connectivity linked to HIV infection and further exasperated by chronic cannabis use. [2] Explore associations between this aberrant connectivity and psychological constructs using meta-analytic functional decoding methods.